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Invitrogen™ Caspase 14 Polyclonal Antibody
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Product Code. 16303565
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Quantity:
100 μL
Unit Size:
100µL
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16303565 100 μL 100µL
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Product Code. 16303565 Supplier Invitrogen™ Supplier No. PA586694

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Description

Rabbit Polyclonal Antibody

Purity is > 95% by SDS-PAGE.

Caspase 14 encodes a member of the cysteine-aspartic acid protease (caspase) family, which plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. Diseases associated with CASP14 include Ichthyosis, Congenital, Autosomal Recessive 12 and Autosomal Recessive Congenital Ichthyosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 14
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Casp14
Gene Accession No. O89094, P31944
Gene Alias apoptosis-related cysteine protease; CASP14; CASP-14; caspase 14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis-related cysteine protease; Caspase14; caspase-14; Caspase-14 subunit p10, mature form; Caspase-14 subunit p17, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form; caspase-14; LOW QUALITY PROTEIN: caspase-14; MICE; Mini-ICE
Gene Symbols Casp14
Host Species Rabbit
Immunogen Synthetic peptide, corresponding to amino acids 163-208 of Human Caspase 14.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12365, 23581, 299587
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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