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Invitrogen™ Caspase 13 Polyclonal Antibody

Product Code. 12848162
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Quantity:
100 μg
Unit Size:
100µg
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12848162 100 μg 100µg
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Product Code. 12848162 Supplier Invitrogen™ Supplier No. PA519949

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~43kDa. A suggested positive control is HL60 cell lysate. PA5-19949 can be used with blocking peptide PEP-0074. The immunogen is located within amino acids 80 - 130 of Caspase-13.

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 13
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CASP13
Gene Accession No. O75601
Gene Alias apoptosis-related cysteine protease; Casp11; CASP-11; CASP13; CASP-13; CASP4; CASP-4; caspase 11; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; caspase 4, isoform alpha, small subunit; Caspase-11; Caspase-13; Caspase-13 subunit 1; Caspase-13 subunit 2; caspase-13A; caspase-13B; caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; Caspase-4 subunit p10; Caspase-4 subunit p20; Caspl; ERICE; Evolutionary related interleukin-1-beta-converting enzyme; Ich3; ich-3; MGC137679; Protease ICH-3
Gene Symbols CASP13
Host Species Rabbit
Immunogen A 15 amino acid peptide near the amino terminus of bovine Caspase-13.
Purification Method Ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 338039, 8628
Target Species Bovine, Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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