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Invitrogen™ Caspase 12 Polyclonal Antibody

Product Code. 12868172
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Quantity:
100 μg
Unit Size:
100µg
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12868172 100 μg 100µg
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Product Code. 12868172 Supplier Invitrogen™ Supplier No. PA519962

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse spleen tissue lysate. PA5-19962 can be used with blocking peptide PEP-0087.

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 12
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CASP12
Gene Accession No. O08736, Q6UXS9, Q920D5
Gene Alias CASP12; CASP-12; CASP12P1; caspase 12; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415; UNQ9415/PRO34398
Gene Symbols CASP12
Host Species Rabbit
Immunogen A 16 amino acid peptide near the amino terminus of murine Caspase-12.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100506742, 12364, 156117
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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