Invitrogen™ Caspase 1 p10/p12 Recombinant Rabbit Monoclonal Antibody (JE56-35)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA556516

Product Code. 30275188

Description

Caspase 1 p10/p12 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

Caspase-1, also known as Interleukin-1β-converting enzyme (ICE), is an inflammatory caspase responsible for processing pro-inflammatory cytokines like IL-1 beta and IL-18, and inducing pyroptosis, a form of programmed cell death. The active form of caspase-1 is a heterotetramer consisting of two p20 and two p10 subunits. The p10 subunit arises from the cleavage of the pro-caspase-1 precursor, which is essential for the enzyme's activation and function. The p12 subunit is a fragment derived from the cleavage of the proenzyme, which is involved in enzyme regulation. Upon activation, caspase-1 cleaves its substrates, leading to the initiation of inflammatory responses and pyroptotic pathways. The regulation of these subunits and their precise activities are crucial for maintaining immune homeostasis and responding to infections and tissue damage.

Specifications

• Antigen: Caspase 1 p10/p12
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P29452, P29466, P43527
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 12362, 25166, 834
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: JE56-35
• Conjugate: Unconjugated
• Gene: CASP1
• Gene Symbols: CASP1
• Immunogen: Recombinant protein within human caspase-1 aa 255-404/404.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG