Casc5 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA555360

Product Code. 15733281

Description

Immunogen sequence: HHTEEDIDKS ANSVLIKNLS RTPSSCSSSL DSIKADGTSL DFSTYRSSQM ESQFLRDTIC EESLREKLQD GRITIREFFI LLQVHILIQK PRQSNLPGNF TVNTPPTPED LMLSQYVYRP KIQIYREDCE ARRQKIEELK LSASNQDKL Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 81%.

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.

Specifications

• Antigen: Casc5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KNL1
• Gene Alias: 2310043D08Rik; 5730505K17Rik; AF15Q14; ALL1-fused gene from chromosome 15q14 protein; Blinkin; blinkin, bub-linking kinetochore protein; Bub-linking kinetochore protein; cancer susceptibility candidate 5; cancer susceptibility candidate gene 5 protein; Cancer/testis antigen 29; CASC5; CT29; D40; hKNL-1; hSpc105; KIAA1570; kinetochore null 1 homolog; kinetochore scaffold 1; Kinetochore-null protein 1; KNL1; MCPH4; microcephaly, primary autosomal recessive 4; PPP1R55; Protein CASC5; Protein D40/AF15q14; protein phosphatase 1, regulatory subunit 55; Rad51; RAD51 homolog; Spc7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57082
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8NG31
• Gene Symbols: KNL1
• Immunogen: Recombinant protein corresponding to Human Casc5
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only