CARF Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA550320

Product Code. 15614255

Description

The antibody detects endogenous levels of total CARF / ALS2CR8 protein.

CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell.

Specifications

• Antigen: CARF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CARF
• Gene Alias: Als2cr8; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein homolog; calcium response factor; calcium responsive transcription factor; calcium-response factor; calcium-response factor CaRF; calcium-responsive transcription factor; CaRF; ECBRC-FC1; ECBRC-FC2; NYD-SP24; testis development protein NYD-SP24
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79800
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q8N187
• Gene Symbols: CARF
• Immunogen: Fusion protein corresponding to residues near the C terminal of human calcium responsive transcription factor
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG