Invitrogen™ Cardiac Troponin T Monoclonal Antibody (1C11cc)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA116687

Product Code. 11568293

Description

This antibody is useful for Troponin T immunoassay. This antibody will work best as a capture for BIAcore. Suggested positive control: antigen standard for TNNT2 (transient overexpression lysate).

Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.

Specifications

• Antigen: Cardiac Troponin T
• Classification: Monoclonal
• Concentration: 5.8 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P45379, P50752, P50753
• Gene Symbols: TNNT2
• Immunogen: Free human cTnT.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 1C11cc
• Conjugate: Unconjugated
• Gene: TNNT2
• Gene Alias: alternatively spliced; cardiac muscle troponin T; cardiac TnT; cardiac troponin 2; cardiac troponin 2 adult #1 isoform; cardiac troponin 2 adult #2 isoform; cardiac troponin 2 embryonic #1 isoform; cardiac troponin 2 embryonic #2 isoform; cardiac troponin 2, exclusion exon 6 #1 isoform; cardiac troponin 2, exclusion exon 6 #2 isoform; cardiac troponin T; cardiac troponin T form I; cardiac troponin T isoform 1; cardiac troponin T isoform 2; cardiac troponin T isoform I; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; MGC3889; RATCTTG; RCM3; TNNT2; Tnnt3; Tnt; TnTc; troponin T; Troponin T cardiac; troponin T cardiac isoform; troponin T isoform 1; troponin T isoform 2; troponin T splicing mutant isoform 1; troponin T splicing mutant isoform 2; troponin T type 2 (cardiac); troponin T, cardiac muscle; Troponin T, cardiac muscle isoforms; Troponin T2; troponin T2, cardiac; troponin T2, cardiac type; truncated cardiac troponin T
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 21956, 24837, 403532, 7139
• Content And Storage: 4°C, do not freeze
• Form: Liquid