Invitrogen™ CARD8 Recombinant Rabbit Monoclonal Antibody (2W3A8)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30282843	Invitrogen™ MA557919	20 μL
30283092	Invitrogen™ MA557920	100 μL

Description

Immunogen sequence: LSGGDIPSVS EEQESSEGQD SGDICSEENQ IVSSYASKVC FEIEEDYKNR QFLGPEGNVD VELIDKSTNR YSVWFPTAGW YLWSATGLGF LVRDEVTVTI.

Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.

Specifications

• Antigen: CARD8
• Concentration: 1.52 mg/mL
• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: Q9Y2G2
• Gene ID (Entrez): 22900
• Immunogen: Synthetic peptide.
• Product Type: Antibody

• Clone: 2W3A8
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: CARD8
• Gene Alias: Apoptotic protein NDPP1; CARD 8; CARD inhibitor of NF-kappaB-activating ligands; CARD8; CARDINAL; CARD-inhibitor of NF-kappa-B-activating ligand; caspase recruitment domain family member 8; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; DACAR; DAKAR; DKFZp779L0366; KI; KIAA0955; NDPP; NDPP1; TUCAN; Tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine
• Gene Symbols: CARD8
• Primary or Secondary: Primary
• Purification Method: Protein A