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Invitrogen™ CARD8 Polyclonal Antibody

Product Code. 12868032
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Quantity:
100 μg
Unit Size:
100µg
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12868032 100 μg 100µg
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Product Code. 12868032 Supplier Invitrogen™ Supplier No. PA520031

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~45kDa. A suggested positive control is K562 cell lysate. PA5-20031 can be used with blocking peptide PEP-0150.

Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CARD8
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CARD8
Gene Accession No. Q9Y2G2
Gene Alias Apoptotic protein NDPP1; CARD 8; CARD inhibitor of NF-kappaB-activating ligands; CARD8; CARDINAL; CARD-inhibitor of NF-kappa-B-activating ligand; caspase recruitment domain family member 8; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; DACAR; DAKAR; DKFZp779L0366; KI; KIAA0955; NDPP; NDPP1; TUCAN; Tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine
Gene Symbols CARD8
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids at the C-terminus of human CARD8.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22900
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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