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Invitrogen™ CARD10 Polyclonal Antibody

Product Code. 12828212
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Quantity:
100 μg
Unit Size:
100µg
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12828212 100 μg 100µg
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Product Code. 12828212 Supplier Invitrogen™ Supplier No. PA519997

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Description

Rabbit Polyclonal Antibody

A suggested positive control is EL4 cell lysate. PA5-19997 can be used with blocking peptide PEP-0119.

CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-Kappa-B activation. When expressed in cells, this protein binds to BCL10 and activates NF-Kappa-B Recent experiments have shown that CARMA3 is required for EGF-induced NF-Kappa-B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CARD10
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CARD10
Gene Accession No. P58660, Q9BWT7
Gene Alias AI449026; Bcl10 binding protein and activator of NFKB; bcl10-interacting MAGUK protein 1; Bimp1; Card10; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; Carma 3; Carma3; caspase recruitment domain family member 10; caspase recruitment domain family, member 10; caspase recruitment domain-containing protein 10
Gene Symbols CARD10
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 14 amino acids at the C-terminus of human CARD10.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 105844, 29775
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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