Invitrogen™ Carbonic Anhydrase IX Monoclonal Antibody (GT12)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA516318

Product Code. 13461047

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Specifications

• Antigen: Carbonic Anhydrase IX
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q16790
• Gene Symbols: CA9
• Immunogen: linear repetitive epitope in the PG region and allows for selective detection of both native and denatured Human CA IX.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: GT12
• Conjugate: Unconjugated
• Gene: CA9
• Gene Alias: Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 768
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid