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  5. Tocris Bioscience™ Capzimin dimer

Tocris Bioscience™ Capzimin dimer
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Product Code. 18756206
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Product Code. 18756206 Supplier Tocris Bioscience™ Supplier No. 6781/10

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Description

Selective proteasome inhibitor

Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC50 = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC50 = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.
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Specifications

Chemical Name or Material 8,8 '-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
CAS 2084868-04-0
Quantity 10 mg
Target Proteasome Inhibitors
Molecular Formula C30H24N6O2S4
Purity 0.98
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