Invitrogen™ Calreticulin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5114934

Product Code. 17297693

Description

Antibody detects endogenous levels of total CALR3.

Calreticulin 3 (CALR3) is a gene located on chromosome 19p13.11, encoding a member of the calreticulin family of calcium-binding chaperones. Unlike the more ubiquitously expressed calreticulin (CALR), CALR3 is specifically expressed in the testes and plays a crucial role in spermatogenesis. CALR3 is involved in the quality control of proteins within the endoplasmic reticulum (ER) and assists in the folding and assembly of newly synthesized glycoproteins. This protein's function is essential for the maturation of sperm cells and male fertility, as it helps ensure the proper formation and function of sperm-specific proteins. Mutations in CALR3 have been associated with familial hypertrophic cardiomyopathy, reflecting its potential involvement in cardiac muscle function through mechanisms that remain to be fully elucidated. Research continues to explore CALR3's specific roles in reproductive biology and its implications in hereditary conditions.

Specifications

• Antigen: Calreticulin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Calr3
• Gene Alias: 1700031L01Rik; 6330586I20Rik; CALR3; calreticulin 3; calreticulin-2; Calreticulin-3; calspeculin; calsperin; cancer/testis antigen 93; CMH19; CRT2; cspn; CT93; EGK_10275; testis secretory sperm-binding protein Li 226n
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 125972, 364529, 73316
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q96L12, Q9D9Q6
• Gene Symbols: Calr3
• Immunogen: A synthesized peptide derived from human CALR3(Accession Q96L12), corresponding to amino acid residues A325-F375.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG