Invitrogen™ Calpain 9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA554197

Product Code. 15752131

Description

Immunogen sequence: PGEYILIPST FEPHQEADFC LRIFSEKKAI TRDMDGNVDI DLPEPPKPTP PDQETEEEQR FRALFEQVAG EDMEVTAEEL EYVLNAVLQK KKDIKFKKLS Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 80%.

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Calpain 9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAPN9
• Gene Alias: 2200003B16Rik; calpain 9; calpain-9; Capn9; Digestive tract-specific calpain; GC36; NCL4; nCL-4; New calpain 4; novel calpain large subunit-4; Protein CG36
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10753
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O14815
• Gene Symbols: CAPN9
• Immunogen: Recombinant protein corresponding to Human Calpain 9. Recombinant protein control fragment (Product #RP-91742).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG