Invitrogen™ Calpain 9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA589435

Product Code. 16587331

Description

Immunogen sequence: QEECSFLVAL MQKDRRKLKR FGANVLTIGY AIYECPDKDE HLNKDFFRYH ASRARSKTFI NLREVSDRFK LPPGEYILIP STFEPHQEAD FCLRIFSEKK AITRDMDGNV DIDLPEPPKP TPPDQETEEE QRFRALFEQV AGEDMEVTAE ELEYVLNAVL QKKKDIKFKK LSLISCKNII SLMDTSGNGK LEFDEFKVFW DKLKQWINLF LRFDADKSGT MSTYELRTAL KAAGFQLSSH LLQLIVLRYA DEELQLDFDD FLNCLVRLEN ASRVFQALST KNKEFIHLNI NEFIHLTMNI; Positive Samples: SGC-7901, HL60, HT-29, Mouse stomach, Mouse small intestine, Rat stomach, Rat small intestine.

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Calpain 9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAPN9
• Gene Alias: 2200003B16Rik; calpain 9; calpain-9; Capn9; Digestive tract-specific calpain; GC36; NCL4; nCL-4; New calpain 4; novel calpain large subunit-4; Protein CG36
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10753, 116694, 73647
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.18 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O14815, O35920, Q9D805
• Gene Symbols: CAPN9
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human CAPN9 (NP_0066061).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG