Invitrogen™ Calpain 7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5103694

Product Code. 16650145

Description

Antibody detects endogenous levels of total CAPN7.

Calpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain-4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain-7). Calpain-7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, calpain-7 has a sequence most closely resembling domain-III, with unknown function. Calpain-7 is widely distributed, found in most tissues analyzed.

Specifications

• Antigen: Calpain 7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAPN7
• Gene Alias: AU022319; calpain 7; calpain like protease; CALPAIN7; calpain-7; Capn7; homolog of Aspergillus Nidulans PALB; palB homolog; PALBH
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12339, 23473, 306260
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9R1S8, Q9Y6W3
• Gene Symbols: CAPN7
• Immunogen: A synthesized peptide derived from human CAPN7(Accession Q9Y6W3), corresponding to amino acid residues I298-D348.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG