Caldesmon/CALD1 Antibody (CALD1/820 + h-CALD) - IHC-Prediluted, Novus Biologicals™

Mouse Monoclonal Antibody

Brand:  Novus Biologicals NBP2-48183

Product Code. 18165188

Description

Caldesmon/CALD1 Monoclonal specifically detects Caldesmon/CALD1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Caldesmon/CALD1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Symbols: CALD1
• Immunogen: Recombinant full-length human Caldesmon/CALD1 protein (Caldesmon/CALD1/820); Crude human uterus extract (h-CALD) (Uniprot: Q05682)
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120'150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70'80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This monoclonal antibody recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Paraffin)
• Clone: CALD1/820 + h-CALD
• Dilution: Immunohistochemistry-Paraffin
• Gene Alias: CAD, caldesmon, caldesmon 1, CDMH-CAD, HCAD, LCAD, L-CAD, MGC21352, NAG22
• Host Species: Mouse
• Molecular Weight of Antigen: 150 kDa
• Quantity: 7 mL
• Research Discipline: Cytoskeleton Markers
• Gene ID (Entrez): 800
• Target Species: Human
• Form: Purified