Invitrogen™ Calcineurin A Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA517446

Product Code. 11596261

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with protein phosphatase 1 or 2A.

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

Specifications

• Antigen: Calcineurin A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PPP3CA
• Gene Alias: 2900074D19Rik; Ca2+/calmodulin-regulated protein phosphatase; calcineurin; calcineurin A alpha; Calcineurin A1; calcineurin catalytic subunit; calcineurin catalytic subunit delta isoform; Calcineurin subunit A alpha; CalcineurinA; calmodulin-dependent calcineurin A subunit alpha isoform; caln; CALNA; CALNA 1; CALNA1; CAM-PRP catalytic subunit; CCN 1; ccn1; CN; CnA; CNA alpha; CNA1; PP2B alpha 1; PP2BA alpha; PP2CB; ppp2b; ppp3ca; ppp3ca.S; protein phosphatase; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isozyme S homeolog; protein phosphatase 3, catalytic subunit, gamma isozyme; protein phosphatase-2Ba; serine/threonine protein kinase; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; XELAEV_18009418mg
• Host Species: Rabbit
• Purification Method: Protein A, Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19055, 24674, 5530
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 10 μg/mL
• Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
• Gene Accession No.: P63328, P63329, Q08209
• Gene Symbols: PPP3CA
• Immunogen: Synthetic peptide corresponding to the carboxy-terminus of human Calcineurin A (alpha isoform).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Monkey, Rat
• Product Type: Antibody
• Isotype: IgG