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Invitrogen™ CACNA2D1 Monoclonal Antibody (20A)
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Product Code. 11555802
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Quantity:
100 μL
Unit Size:
100µL
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11555802 100 μL 100µL
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Product Code. 11555802 Supplier Invitrogen™ Supplier No. MA3921

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Description

Mouse Monoclonal Antibody

MA3-921 detects 1,4-dihydropyridine (DHP) receptor alpha-2 subunit from human, rat, mouse, guinea pig and rabbit skeletal and cardiac muscle. MA3-921 has been successfully used in Western blot, immunocytochemistry, immunofluorescence, and immunohistochemistry procedures. By Western blot, this antibody detects a 220 kDa protein under non-reducing and a 143 kDa protein under reducing conditions representing DHP from rabbit skeletal muscle membrane preparations. Immunohistochemical staining of DHP in rabbit skeletal muscle with MA3-921 results in double rows of discrete punctate staining representing pairs of triads on the opposing sides of the Z-lines. The MA3-921 antigen is purified rabbit DHP receptor.

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CACNA2D1
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 20A
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.05% sodium azide
Gene Cacna2d1
Gene Accession No. O08532, P13806, P54289, P54290
Gene Alias Ca(v)alpha2delta1; Cacna2; Cacna2d1; CACNL2A; Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type); calcium channel, L type, alpha 2 polypeptide; calcium channel, voltage-dependent, alpha 2/delta subunit 1; calcium channel, voltage-dependent, alpha2/delta subunit 1; calcium voltage-gated channel auxiliary subunit alpha2delta 1; CCHL2A; CCHLA2; DHP; DHSCCA; dihydropryridine-sensitive calcium channel alpha-2 subunit; dihydropyridine-sensitive calcium channel alpha 2; dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit; H_DJ0560O14.1; LINC01112; lncRNA-N3; MHS3; unknown protein; voltage-dependent calcium channel alpha-2 delta subunit precursor; Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; WUGSC:H_DJ0560O14.1
Gene Symbols Cacna2d1
Host Species Mouse
Immunogen Purified rabbit dihydropyridine receptor.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100009105, 100728887, 12293, 25399, 781
Target Species Guinea Pig, Human, Mouse, Rabbit, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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