Invitrogen™ CABYR Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA537145

Product Code. 15594261

Description

This antibody detects endogenous protein at a molecular weight of 30 and 53 kDa. Purity is >95% by SDS-PAGE.

Spermatozoa gain fertilization capacitation and hyperactivation after residing in the uterus or oviduct. Calcium, cAMP and protein tyrosine phosphorylation are necessary for the molecular mechanisms that allow for this transformation. CABYR (Calcium-binding tyrosine phosphorylation-regulated protein), also known as Fibrousheathin-2 or Cancer/testis antigen 88, is a 493 amino acid protein that is expressed in sperm flagella and exhibits increased tyrosine phosphorylation during capacitation. There are six named isoforms of CABYR that are produced as a result of alternative slicing events. Specifically, isoform 1 is expressed in the testis, while isoform 3 and isoform 5 are expressed in pancreas, brain and various brain tumors. Isoforms 1, 2 and 6 most likely bind calcium, whereas isoforms 3, 4 and 5 probably do not bind calcium.

Specifications

• Antigen: CABYR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CABYR
• Gene Alias: 1700016C01Rik; 4933421A18Rik; Cabyr; CABYRa; CABYRc; CABYRc/d; CABYRe; calcium binding tyrosine phosphorylation regulated; calcium binding tyrosine-(Y)-phosphorylation regulated; calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); calcium-binding protein 86; Calcium-binding tyrosine phosphorylation-regulated protein; calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); calcium-binding tyrosine-phosphorylation regulated protein; cancer/testis antigen 88; CBP86; CT88; fibrousheathin 2; fibrousheathin II; Fibrousheathin-2; FSP2; FSP-2; testis tissue sperm-binding protein Li 84P; testis-specific calcium-binding protein CBP86
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26256, 686189, 71132
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75952, Q9D424
• Gene Symbols: CABYR
• Immunogen: A synthetic peptide corresponding to residues in human CABYR.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG