C4 gamma chain Mouse anti-Human, Clone: 2G6A7, Proteintech

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16867935	Proteintech 66242-1-IG-20UL	20 μL
16857935	Proteintech 66242-1-IG-150UL	150 μL

Description

This antibody raised against 1543-1744aa of human C4-A protein recognizes C4 gamma chain.

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

Specifications

• Antigen: C4 gamma chain
• Concentration: 0.81 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Acidic complement C4, C4, C4A, C4A2, C4A3, C4A4, C4A6, C4S, CO4, Complement C4 A, CPAMD2, RG
• Gene Symbols: C4A
• Isotype: IgG1
• Purification Method: Protein G
• Product Type: Antibody

• Clone: 2G6A7
• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: P0C0L4
• Gene ID (Entrez): 720
• Immunogen: C4 gamma chain Fusion Protein Ag10449
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: C4A