Invitrogen™ C1orf57 Monoclonal Antibody (2C3)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA522745

Product Code. 15549162

Description

Peptide Sequence: LALPVLRNAD CSSGPGQRVC VIDEIGKMEL FSQLFIQAVR QTLSTPGTII LGTIPVPKGK PLALVEEIRN RKDVKVFNVT KENRNHLLPD IVTCVQSSRK.

Belonging to the THEP1 NTPase family, C1orf57 (also known as nucleoside triphosphate phosphohydrolase), and its mouse homolog, 2310079N02Rik, are 190 amino acid proteins that has nucleotide phosphatase activity towards ATP, GTP, TTP, CTP and UTP. Acting as a monomer, it also hydrolyzes nucleoside diphosphates with lower efficiency. The gene encoding C1orf57 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Specifications

• Antigen: C1orf57
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9BSD7
• Gene Symbols: Ntpcr
• Immunogen: NTPCR (NP_115700, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot
• Clone: 2C3
• Conjugate: Unconjugated
• Gene: Ntpcr
• Gene Alias: 2310079N02Rik; AI449709; C1orf57; cancer-related nucleoside-triphosphatase; Cancer-related nucleoside-triphosphatase homolog; CH1073-266P11.1; HCR-NTPase; NTPase; Ntpcr; Nucleoside triphosphate phosphohydrolase; nucleoside-triphosphatase C1orf57 homolog; nucleoside-triphosphatase, cancer-related; RGD1306192; RP4-659I19.2; RP4-678E16.2; zgc:92420
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84284
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid