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Invitrogen™ c-Fos Monoclonal Antibody (2G9C3)
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Product Code. 11593893
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Quantity:
100 μg
Unit Size:
100µg
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11593893 100 μg 100µg
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Product Code. 11593893 Supplier Invitrogen™ Supplier No. MA121190

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Description

Mouse Monoclonal Antibody

This antibody does not cross-react with the 39 kDa jun protein. By Western blot, this antibody detects ~55 & 62 kDa bands representing c-fos and v-fos, respectively. MA1-21190 is not suitable for IHC applications on frozen or paraffin tissues. Positive control of HeLa Cells suggested.

FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen c-Fos
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2G9C3
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation 0.05M sodium phosphate with 0.2% gelatin and 0.1% sodium azide; pH 7.5
Gene FOS
Gene Accession No. P01100, P01101, P12841
Gene Alias activator protein 1; AP-1; cellular oncogene c-fos; cellular oncogene fos; cFos; C-FOS; c-fos oncogene; c-fos protooncogene protein; D12Rfj1; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FBJ murine osteosarcoma viral oncogene homolog B; FBJ osteosarcoma oncogene; FBJ osteosarcoma oncogene B; FBJ osteosarcoma viral oncogene isoform deltaFosb-2; FOS; Fos proto-oncogene, AP-1 trancription factor subunit; Fos proto-oncogene, AP-1 transcription factor subunit; Fosb; FosB proto-oncogene, AP-1 transcription factor subunit; fra-2; G0/G1 switch regulatory protein 7; G0S7; I79_009428; p55; protein fosB; proto-oncogene cFOS; proto-oncogene c-Fos; proto-oncogene protein c-fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
Gene Symbols FOS
Host Species Mouse
Immunogen Synthetic peptide: KVEQLSPEEEEKRRIRRERNKMAAA, corresponding to Internal sequence amino acids 128-152 of Human c-Fos.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14281, 2353, 314322
Target Species Human, Mouse, Rat
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a
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