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Butein, MedChemExpress

Product Code. 16437078
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Product Code. 16437078

Brand: Medchem Express HY16558

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Description

MedChemExpress Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC).

Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC).

Specifications

Chemical Name or Material Butein
CAS 487-52-5
Color Brownish Yellow
Purity Grade Notes Research
Molecular Formula C15H12O5
Quantity 10 mg
Synonym 2’,3,4,4’-tetrahydroxy Chalcone
Solubility Information DMSO : 50 mg/mL (183.65 mM; Need ultrasonic)
SMILES OC1=CC=C(C(/C=C/C2=CC(O)=C(O)C=C2)=O)C(O)=C1
Molecular Weight (g/mol) 272.25
Formula Weight 272.25
Percent Purity 98.01%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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