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Invitrogen™ BRSK1 Polyclonal Antibody

Product Code. 12808542
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Quantity:
100 μg
Unit Size:
100µg
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12808542 100 μg 100µg
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Product Code. 12808542 Supplier Invitrogen™ Supplier No. PA520353

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue lysate. PA5-20353 can be used with blocking peptide PEP-0473.

BRSK1 (SAD1) is a serine/threonine kinase, and is a UV-induced DNA damage checkpoint kinase. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BRSK1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Brsk1
Gene Accession No. B2DD29, Q5RJI5, Q8TDC3
Gene Alias BR serine/threonine kinase 1; BR serine/threonine-protein kinase 1; Brain-selective kinase 1; brain-specific serine/threonine-protein kinase 1; Brsk1; Gm1100; hSAD1; KIAA1811; protein kinase SAD1A; RGD1563268; SAD1; SAD1 homolog; SAD1 kinase; SAD1A; SADB; SAD-B; SadB kinase short isoform; serine/threonine kinase SADB; serine/threonine kinase SAD-B; serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1
Gene Symbols Brsk1
Host Species Rabbit
Immunogen a 28 amino acid peptide from near the center of human BRSK1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 381979, 499073, 84446
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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