Invitrogen™ Brevican Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA531444

Product Code. 13465967

Description

Recommended positive controls: BCAN-transfected 293T. Predicted reactivity: Mouse (92%), Rat (93%), Dog (97%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.

Specifications

• Antigen: Brevican
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Bcan
• Gene Alias: ALPBRE; Bcan; Behab; Brain-enriched hyaluronan-binding protein; brevican; brevican (brain specific proteoglycan in the aggrecan family); brevican core protein; Chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB; CSPG7; UNQ2525/PRO6018
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 63827
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q96GW7
• Gene Symbols: Bcan
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human Brevican. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG