Invitrogen™ Brevican Polyclonal Antibody

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
17790394	Invitrogen™ PA5118986	200 μL
17763584	Invitrogen™ PA5122188	20 μL

Description

Brevican Polyclonal Antibody for Western Blot, IHC (P)

Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.

Specifications

• Antigen: Brevican
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Mouse, Rat
• Gene: Bcan
• Gene Alias: ALPBRE; Bcan; Behab; Brain-enriched hyaluronan-binding protein; brevican; brevican (brain specific proteoglycan in the aggrecan family); brevican core protein; Chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB; CSPG7; UNQ2525/PRO6018
• Gene Symbols: Bcan
• Primary or Secondary: Primary
• Purification Method: Antigen affinity chromatography, Protein A

• Concentration: 0.5 mg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: P55068, Q61361
• Gene ID (Entrez): 12032, 25393
• Immunogen: Recombinant protein Brevican. The antigen corresponds to amino acid range 23-353 of the target protein.
• Product Type: Antibody