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Invitrogen™ BRE Polyclonal Antibody

Product Code. 12858472
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Quantity:
100 μg
Unit Size:
100µg
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12858472 100 μg 100µg
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Product Code. 12858472 Supplier Invitrogen™ Supplier No. PA520415

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Hela cell lysate. PA5-20415 can be used with blocking peptide PEP-0532.

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BRE
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene BABAM2
Gene Accession No. Q6P7Q1, Q8K3W0, Q9NXR7
Gene Alias 6030405P19Rik; AI429776; B830038C02Rik; BABAM2; brain and reproductive organ-expressed (TNFRSF1A modulator); brain and reproductive organ-expressed protein; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; BRCA1-A complex subunit BRE; BRCC4; BRCC45; BRE; bre {ECO:0000312; BRISC and BRCA1-A complex member 2; RGD:735111}
Gene Symbols BABAM2
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the amino terminus of human BRCC45.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107976, 362704, 9577
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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