Invitrogen™ BRE Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5101993

Product Code. 16678464

Description

Antibody detects endogenous levels of total BRE.

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Specifications

• Antigen: BRE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BABAM2
• Gene Alias: 6030405P19Rik; AI429776; B830038C02Rik; BABAM2; brain and reproductive organ-expressed (TNFRSF1A modulator); brain and reproductive organ-expressed protein; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; BRCA1-A complex subunit BRE; BRCC4; BRCC45; BRE; bre {ECO:0000312; BRISC and BRCA1-A complex member 2; RGD:735111}
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107976, 362704, 9577
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q6P7Q1, Q8K3W0, Q9NXR7
• Gene Symbols: BABAM2
• Immunogen: A synthesized peptide derived from human BABAM2(Accession Q9NXR7), corresponding to amino acid residues T324-Q374.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG