Invitrogen™ BRD9 Recombinant Rabbit Monoclonal Antibody (8C4G2)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA551462

Product Code. 18065941

Description

Immunogen sequence: REVISCMFEP EGNACSLTDS TAEEHVLALV EHAADEARDR INRFLPGGKM GYLKRNGDGS LLYSVVNTAE PDADEEETHP VDLSSLSSKL LPGFTTLGFK DERRNKVTFL SSATTALSMQ NNSVFGDLKS DEMELLYSAY GDETGVQCAL SLQEFVKDAG SYSKKVVDDL LDQITGGDHS RTLFQLKQRR NVPMKPPDEA KVGDTLGDSS SSVLEFMSMK SYPDVSVDIS MLSSLGKVKK ELDPDDSHLN LDETTKLLQD LHEAQAERGG SRPSSNLSSL SNASERDQHH LGSPSRLSVG EQPDVTHDPY EFLQSPEPAA SAKT.

The BRD9 gene encodes a protein that is a crucial subunit of the SWI/SNF chromatin remodeling complex known as ncBAF (non-canonical BAF complex). As a bromodomain-containing protein, BRD9 acts as an 'epigenetic reader,' selectively recognizing acetyl-lysine marks on histones, which is essential for regulating chromatin structure and gene expression through the recruitment of acetylated transcriptional regulators. It has emerged as a significant player in epigenetic modulation and has been implicated in various cancers, such as cervical and non-small cell lung cancer, due to its over-expression. BRD9 is situated on the 5p arm of chromosome 5 and is a potential target for anticancer therapies, notably in acute myeloid leukemia (AML). Recent studies highlight the development of selective BRD9 inhibitors, indicating its potential for therapeutic targeting. Its role in cancer is linked to its function in transcriptional regulation and its involvement in the mammalian SWI/SNF complex, which is linked to tumor suppression mechanisms.

Specifications

• Antigen: BRD9
• Classification: Recombinant Monoclonal
• Concentration: 0.07 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q3UQU0, Q9H8M2
• Gene Symbols: BRD9
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 274-597 of human BRD9 (NP_076413.3).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Western Blot
• Clone: 8C4G2
• Conjugate: Unconjugated
• Gene: BRD9
• Gene Alias: AL022779; Brd9; bromodomain containing 9; bromodomain-containing protein 9; DKFZp434D0711; DKFZp686L0539; FLJ43530; LAVS3040; PRO9856; rhabdomyosarcoma antigen MU-RMS-40.8; sarcoma antigen NY-SAR-29; UNQ3040/PRO9856
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105246, 308067, 65980
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG