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Branaplam, MedChemExpress

Product Code. p-200098975
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Product Code. 16497818

Brand: Medchem Express HY19620

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Description

MedChemExpress Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.

Branaplam (LMI070

Specifications

Chemical Name or Material Branaplam
CAS 1562338-42-4
Color Yellow
Purity Grade Notes Research
Molecular Formula C22H27N5O2
Quantity 10 mg
Synonym LMI070 NVS-SM1
Solubility Information DMSO : 5 mg/mL (12.71 mM; ultrasonic and warming and heat to 80°C)
SMILES OC1=CC(C2=CNN=C2)=CC=C1C3=CC=C(OC4CC(C)(C)NC(C)(C)C4)N=N3
Molecular Weight (g/mol) 393.48
Formula Weight 393.48
Percent Purity 95.62%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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