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  6. Bortezomib, 98%

Bortezomib, 98%

Product Code. 15473159
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25 mg
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25mg
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Product Code. 15473159

Brand: Thermo Scientific Alfa Aesar J60378.MB

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Description

Bortezomib (CAS # 179324-69-7) is an inhibitor of protein degradation pathways. | CAS: 179324-69-7 | C19H25BN4O4 | 384.243 g/mol

A potent, highly selective and reversible inhibitor of the 20S proteasome, Bortezomib is used as an antineoplastic agent, which controls the growth of cancer cells. It is also useful in the treatment of multiple myeloma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Bortezomib is an antineoplastic compound derived from boronic acid
• Bortezomib reversibly inhibits the 26S proteostome that maintains cell cycle pathways related to growth and division
• Bortezomib is an inhibitor of NF-κB, a factor that is constituitively active in some cancers

Application

• Bortezomib is suitable for use in the research of multiple myeloma and lymphomas, and for use in the research of protein degradation pathways
• Bortezomib is intended for in vitro and biochemical applications

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 179324-69-7
Molecular Formula C19H25BN4O4
Molecular Weight (g/mol) 384.243
MDL Number MFCD09056737
InChI Key GXJABQQUPOEUTA-RDJZCZTQSA-N
Synonym bortezomib, velcade, bortezomib ps-341, dpba, pyz-phe-boroleu, unii-69g8bd63pp, velcade tn, bortezomib velcade, 1r-3-methyl-1-2s-1-oxo-3-phenyl-2-pyrazinylcarbonyl amino propyl amino butyl boronic acid, 1r-3-methyl-1-2s-3-phenyl-2-pyrazine-2-carbonylamino propanoyl amino butyl boronic acid
PubChem CID 387447
ChEBI CHEBI:52717
IUPAC Name [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
SMILES B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

Specifications

Melting Point 139°C to 143°C
Color Brown to White
Quantity 25 mg
UN Number UN3249
Merck Index 14,1351
Solubility Information Soluble in chloroform,dimethyl sulfoxide,ethanol and methanol.
Formula Weight 384.24
Percent Purity 99%
Physical Form Powder
Chemical Name or Material Bortezomib

RUO – Research Use Only

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