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Tocris Bioscience™ Bortezomib
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Product Code. 18788286
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
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Product Code. 18788286

Brand: Tocris Bioscience™ 7282/25

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This item is not returnable. View return policy

Description

High affinity proteasome inhibitor

Bortezomib is a high affinity proteasome inhibitor (Ki = 0.6 nM). Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines. Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs). Acts synergistically with dexamethasone (Cat. No. 1126). Also cytotoxic in MCF-7 breast cancer cell line (IC50 = 50 nM).
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Specifications

Chemical Name or Material B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
CAS 179324-69-7
Quantity 25 mg
Target Proteasome Inhibitors
Molecular Formula C19H25BN4O4
Purity 0.98
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