Invitrogen™ BNIP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA529977

Product Code. 13464387

Description

Recommended positive controls: Jurkat, Raji, NCI-H929. Predicted reactivity: Mouse (91%), Rat (92%), Zebrafish (80%), Xenopus laevis (86%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.

Specifications

• Antigen: BNIP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Bnip2
• Gene Alias: 5730523P12Rik; Bcl-2 and E1B 19 kDa interacting protein; BCL2 interacting protein 2; BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; BCL2/adenovirus E1B 19 kDa-interacting protein 2 beta; BCL2/adenovirus E1B 19kDa interacting protein 2; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2; BCL2/adenovirus E1B interacting protein 1, NIP2; BCL2/adenovirus E1B interacting protein 2; BNIP 2; BNIP2; BNIP-2; BNIP2beta; NIP2; Nip21; Nip2l
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 300811, 663
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.02 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q12982
• Gene Symbols: Bnip2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human BNIP2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG