BLNK (phospho Y84) Rabbit anti-Human, Mouse, Rat, Polyclonal , Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human BLNK.

Brand:  Abnova PAB29646.100uL

Product Code. 16254360

Description

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: BLNK (phospho Y84)
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human BLNK.
• Formulation: In PBS (without Mg²⁺ and Ca²⁺), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Symbols: BLNK
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y84 of human BLNK.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: BLNK (phospho Y84) polyclonal antibody detects endogenous levels of human BLNK only when phosphorylated at tyrosine 84.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:3000) The optimal working dilution should be determined by the end user.
• Gene Alias: BASH/BLNK-S/LY57/MGC111051/SLP-65/SLP65
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29760
• Target Species: Human, Mouse, Rat
• Form: Liquid