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  5. STEMCELL Technologies (-)-Blebbistatin

STEMCELL Technologies (-)-Blebbistatin

Product Code. 17160062
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25 mg
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17160062 25 mg 25mg
17150062 5 mg 5mg
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Product Code. 17160062 Supplier STEMCELL Technologies Supplier No. 72404

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Description

Non-muscle myosin II (NM II) ATPase inhibitor

  • (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases (Kovács et al.; Straight et al.) It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM) (Limouze et al.)
  • Increases human pluripotent stem cell (hPSC) survival and cloning efficiency after dissociation to single cells, downstream of ROCK inhibition (Chen et al.; Ohgushi et al.; Walker et al.; Xu et al.)
  • Enables hPSC to be cultured on microcarriers without surface coating (Chen et al.)
  • Inhibits differentiation of human mesenchymal stem cells (McBeath et al.; Engler et al.)

Specifications

CAS 856925-71-8
Quantity 25 mg
Molecular Formula C18H16N2O2
Purity ≥98%
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