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BIX-01294, MedChemExpress

Product Code. 16484058
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 16484058

Brand: Medchem Express HY10587

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Description

MedChemExpress BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells.

BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells.

Specifications

Chemical Name or Material BIX-01294
CAS 935693-62-2
Color Off-White
Purity Grade Notes Research
Molecular Formula C28H38N6O2
Quantity 10 mg
Solubility Information DMSO : ≥ 110 mg/mL (224.20 mM) ∣H2O : 1 mg/mL (2.04 mM; Need ultrasonic)
SMILES COC1=C(OC)C=C(C(NC2CCN(CC3=CC=CC=C3)CC2)=NC(N4CCN(C)CCC4)=N5)C5=C1
Molecular Weight (g/mol) 490.64
Formula Weight 490.64
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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