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  5. Tocris Bioscience™ BIRB 796

Tocris Bioscience™ BIRB 796
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Product Code. 18757996
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18757996

Brand: Tocris Bioscience™ 5989/10

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This item is not returnable. View return policy

Description

High affinity and selective p38 kinase inhibitor

BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). Cell permeable.
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Specifications

Chemical Name or Material N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
CAS 285983-48-4
Synonym Doramapimod
Quantity 10 mg
Target p38 Inhibitors
Molecular Formula C31H37N5O3
Formula Weight 527.66
Purity 0.98
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