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  4. ACROBiosystems Biotinylated Cynomolgus Fc gamma RIII / CD16 Protein, His, Avitag™ (BLI verified)

ACROBiosystems Biotinylated Cynomolgus Fc gamma RIII / CD16 Protein, His, Avitag™ (BLI verified)

Product Code. 15866717
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200 μg
25 μg
Unit Size:
200µg
25µg
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15866717 25 μg 25µg
15856717 200 μg 200µg
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Product Code. 15866717 Supplier ACROBiosystems Supplier No. FC6C82E025UG

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Description

Biotinylated BLI verified Protein

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody­dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 25.7 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_001270121.1(R25K)
Molecular Weight (g/mol) 25.7 kDa
Quantity 25 μg
Source Biotinylated Cynomolgus CD16, His,Avitag (BLI verified) (FC6-C82E0) is expressed from human 293 cells (HEK293). It contains AA Gly 17 - Gln 208 (Accession # Q8SPW2-1).
Immunogen Gly 17 - Gln 208
Storage Requirements -20°C
Gene Alias FCGR3
Common Name Fc gamma RIII / CD16
Conjugate Precision Avi
Species Cynomolgus Monkey
Protein Tag His Tag and Avi Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype MABSol™ Biotin Labeled Proteins
Purity or Quality Grade >95% as determined by SDS-PAGE
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