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  4. ACROBiosystems Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His, Avitag™ (SPR & BLI verified)

ACROBiosystems Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His, Avitag™ (SPR & BLI verified)

Product Code. 16497349
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200 μg
25 μg
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200µg
25µg
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16497349 200 μg 200µg
16407359 25 μg 25µg
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Product Code. 16497349 Supplier ACROBiosystems Supplier No. CDBC82E4200ug

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Description

Biotinylated Protein

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 23.6 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_001271060.1
Molecular Weight (g/mol) 23.6 kDa
Quantity 200 μg
Source Biotinylated Cynomolgus CD32b, His,Avitag (SPR and BLI verified) (CDB-C82E4) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 224 (Accession # Q8SPW3-1).
Immunogen Ala 46 - Pro 224
Storage Requirements -20°C
Gene Alias FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32
Common Name Fc gamma RIIB / CD32b
Conjugate Precision Avi
Species Cynomolgus Monkey
Protein Tag His Tag and Avi Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype MABSol™ Biotin Labeled Proteins
Purity or Quality Grade >95% as determined by SDS-PAGE
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