Invitrogen™ Biliverdin Reductase Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5118981

Product Code. 17740394

Description

Biliverdin Reductase Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin. BLVR is unique among all enzymes to date in being dual pH/dual cofactor-dependent, as it requires NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor. There are two isoforms of BLVR, biliverdin-IX alpha-reductase (BLVRA), the major component of human adult liver, and biliverdin-IX beta-reductase (BLVRB), found predominantly in fetal liver. The product of BLVR, bilirubin, is an important biological antioxidant, however it is also a neurotoxin and the cause of kernicterus. In addition to being an antioxidant, it inhibits kinase activity and the activity of enzymes such as protein kinase C and NADPH oxidase.

Specifications

• Antigen: Biliverdin Reductase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Blvra
• Gene Alias: 0610006A11Rik; 2500001N03Rik; Biliverdin reductase A; biliverdin reductase A-like protein; biliverdin-IX alpha-reductase; BLVR; Blvra; BVR; BVR A; BVRA; EC 1.3.1.24; testis tissue sperm-binding protein Li 61n
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 109778, 116599, 644
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: P46844, P53004, Q9CY64
• Gene Symbols: Blvra
• Immunogen: Recombinant protein Biliverdin Reductase A. The antigen corresponds to amino acid range 1-125 of the target protein.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG