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  6. Invitrogen™ BID Recombinant Mouse Monoclonal Antibody (K40084_20C7)

Invitrogen™ BID Recombinant Mouse Monoclonal Antibody (K40084_20C7)

Product Code. 30827392
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30828568 100 μL
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Product Code. 30827392 Supplier Invitrogen™ Supplier No. MA565943
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Estimated Shipment: 11-09-2026
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Description

Mouse Recombinant Monoclonal Antibody

Immunogen sequence: GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 57%, Pig - 60%, Cynomolgus monkey - 97%.

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BID
Applications Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone K40084_20C7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.5% BSA, 50% glycerol and 0.09% sodium azide
Gene BID
Gene Accession No. P55957
Gene Alias 2700049M22Rik; AI875481; apoptic d; apoptic death agonist; apoptotic death agonist BID; AU022477; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; Bid; BID isoform ES(1b); BID isoform L(2); BID isoform Si6; desmocollin type 4; FP497; HGNC:1050; Human BID coding sequence; MGC15319; MGC42355; OTTHUMP00000196197; p11 BID; p13 BID; p15 BID; p22 BID
Gene Symbols BID
Host Species Mouse
Immunogen Recombinant human BID (aa 61-150).
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 637
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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