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BI-749327, MedChemExpress

Product Code. 16497257
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Product Code. 16497257 Supplier Medchem Express Supplier No. HY111925

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Description

MedChemExpress BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.

BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.

Specifications

Chemical Name or Material BI-749327
CAS 2361241-23-6
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C23H21F3N4O2
Quantity 5 mg
Solubility Information DMSO : 31.25 mg/mL (70.63 mM; Need ultrasonic)
SMILES NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1
Molecular Weight (g/mol) 442.43
Formula Weight 442.43
Percent Purity 98.49%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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