Betulinic acid, Tocris Bioscience™

Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist

Brand:  Tocris Bioscience 3906/10

Product Code. 18084452

Description

Betulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%). Betulinic acid suppresses areobic glycolysis by regulating the Cav-1/NF-κB/c-Myc pathway in and inhibits growth in breast cancer cells.

Chemical Identifiers

• CAS: 472-15-1
• Molecular Weight (g/mol): 456.711
• Synonym: betulinic acid, mairin, betulic acid, ccris 6748, 3-hydroxylup-20 29-en-28-oic acid, 3beta-hydroxy-20 29-lupaene-28-oic acid, 3beta-hydroxy-lup-20 29-en-28-oic acid, lup-20 29-en-28-oic acid, 3-hydroxy-, 3beta, 1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br-9-hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta a chrysene-3a-carboxylic acid, 1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta a chrysene-3a-carboxylic acid
• ChEBI: CHEBI:3087
• SMILES: CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O

• Molecular Formula: C30H48O3
• InChI Key: QGJZLNKBHJESQX-FZFNOLFKSA-N
• PubChem CID: 64971
• IUPAC Name: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

Specifications

• CAS: 472-15-1
• Quantity: 10 mg
• InChI Key: QGJZLNKBHJESQX-FZFNOLFKSA-N
• IUPAC Name: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
• PubChem CID: 64971
• Formula Weight: 456.7
• Chemical Name or Material: Betulinic acid

• Molecular Formula: C30H48O3
• Synonym: betulinic acid, mairin, betulic acid, ccris 6748, 3-hydroxylup-20 29-en-28-oic acid, 3beta-hydroxy-20 29-lupaene-28-oic acid, 3beta-hydroxy-lup-20 29-en-28-oic acid, lup-20 29-en-28-oic acid, 3-hydroxy-, 3beta, 1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br-9-hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta a chrysene-3a-carboxylic acid, 1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta a chrysene-3a-carboxylic acid
• SMILES: CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O
• Molecular Weight (g/mol): 456.711
• ChEBI: CHEBI:3087
• Percent Purity: >98%