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  6. Invitrogen™ beta Dystroglycan Recombinant Rabbit Monoclonal Antibody (K01_2L55)

Invitrogen™ beta Dystroglycan Recombinant Rabbit Monoclonal Antibody (K01_2L55)

Product Code. 30826380
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30826380 100 μL
30830268 50 μL
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Product Code. 30826380 Supplier Invitrogen™ Supplier No. MA564008

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: EGKGSRPKNM TPYR.

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen beta Dystroglycan
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_2L55
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 150mM NaCl, 40% glycerol, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene DAG1
Gene Accession No. Q14118
Gene Alias 156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9
Gene Symbols DAG1
Host Species Rabbit
Immunogen A synthetic peptide of human beta Dystroglycan (aa 874-887).
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1605
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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