beta-Catenin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B8A1, Proteintech

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16838205	Proteintech 66379-1-IG-20UL	20 μL
16828205	Proteintech 66379-1-IG-150UL	150 μL

Description

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintece of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation.

Specifications

• Antigen: beta-Catenin
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286
• Gene Symbols: CTNNB1
• Isotype: IgG1
• Purification Method: Protein G
• Product Type: Antibody

• Clone: 1B8A1
• Applications: Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Mouse, Rat, Human, Pig
• Gene Accession No.: P35222, Q02248, Q9WU82
• Gene ID (Entrez): 12387, 1499, 397657, 84353
• Immunogen: Peptide
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CTNNB1