Invitrogen™ beta-2 Defensin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5107328

Product Code. 17127133

Description

Product is supplied at 1 mL (100 μL/mL). Application Notes: Western Blot - Test was performend under reduced sample treatment using SDS-Page. The band size is 25kDa for recombinant protein with tag and 5 kDa for the native protein. IHC-P- Tissue sections were pretreated with high temperature citrate and fixed in formalin. PBS was used as a negative control.

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.

Specifications

• Antigen: beta-2 Defensin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DEFB4A
• Gene Alias: BD-2; beta defensin 2; beta defensin-2; Beta-defensin 2; Beta-defensin 4A; DEFB102; DEFB2; DEFB-2; DEFB4; DEFB4A; DEFB4B; Defensin beta 2; defensin beta 4A; Defensin beta2; defensin, beta 2; defensin, beta 4; defensin, beta 4A; Defensin-beta2; HBD-2; SAP1; Skin-antimicrobial peptide 1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1673
• Content And Storage: 4°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene Accession No.: O15263
• Gene Symbols: DEFB4A
• Immunogen: CHPVFCPRRYKQIGTCGL.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG