Invitrogen™ beta-2 Adrenergic Receptor Chimeric Recombinant Rabbit Monoclonal Antibody (13D6)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA548305

Product Code. 17981491

Description

Specificity: 13D6 antibody recognizes human beta-2 adrenergic receptor. It was reported that this antibody recognizes extracellualr domains of the receptor. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline.

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.

Specifications

• Antigen: beta-2 Adrenergic Receptor Chimeric
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: P07550
• Gene Symbols: Adrb2
• Immunogen: This antibody was raised by immunizing mice with beta-2 adrenergic receptor.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG κ

• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 13D6
• Conjugate: Unconjugated
• Gene: Adrb2
• Gene Alias: Adrb2; Adrb-2; ADRB2R; ADRBR; Adrenergic beta 2- receptor surface; adrenergic receptor beta 2; adrenergic receptor, beta 2; adrenergic, beta-2, receptor, surface; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; AR beta2; B2AR; Badm; BAR; beta 2-AR; beta-2 adrenergic receptor; Beta-2 adrenoceptor; beta-2 adrenoreceptor; beta-2-adrenergic receptor; beta2-adrenergic receptor; beta2-Adrenoreceptor; BETA2AR; catecholamine receptor; Gpcr7; HGNC:286
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 154
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid