BD Caspase-8

Product Code.	Concentration	unitSize
15808718	0.2mg/mL	Each

Product Code. 15808718

Brand: BD 556481

Description

Play role in apoptosis induced by death receptors

Caspases are cysteine proteases that play central role in apoptosis. The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C. elegans death gene that is required for normal apoptosis during development

• Fas and tumor necrosis factor receptor type 1 (TNFR1)
• One of its substrates is poly (ADP ribose) polymerase (PARP)
• PARP is an enzyme that is involved in DNA repair and genomic maintenance
• Cleaves PARP from its 116kDa form to 85kDa residual fragment
• The cleavage site in PARP is C-terminal to Asp-216
• Utilized as basis for highly specific caspase-3 substrates such as Ac(N-acetyl)-DEVD-AFC (7-amino-4-trifluoromethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin) as well as caspase-3 aldehyde inhibitor Ac-DEVD-CHO
• Format: Purified

Fluorescence quantitation

Specifications

• Concentration: 0.2mg/mL
• For Use With (Application): Fluorescence Quantitation
• Name: Human Caspase-8 Protease Recombinant Protein
• Quantity: 5μg
• Storage Requirements: -80°C
• Cross Reactivity: Human
• Recombinant: Recombinant

Research use only