BCR Mouse anti-Human, Clone:6B5E12, Abnova™

Mouse monoclonal antibody raised against partial recombinant human BCR.

Brand:  Abnova MAB17934.100ug

Product Code. 16095216

Description

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: BCR
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Western Blot (1:100-1:500)
  The optimal working dilution should be determined by the end user.
• Gene: BCR
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 6B5E12
• Description: breakpoint cluster region
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: ALL, BCR-ABL1, BCR1, CML, D22S11, D22S662, FLJ16453, PHL
• Immunogen: Recombinant protein corresponding to amino acids 139-280 of human BCR.
• Gene ID (Entrez): 613
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid